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Bend Research Expands HME Capacity

Adds Leistritz twin-screw mixer/extruder

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By: Tim Wright

Editor-in-Chief, Contract Pharma

Bend Research has expanded its existing hot-melt extrusion (HME) capacity with the addition of an 18mm Leistritz twin-screw mixer/extruder, enhancing the company’s melt-extrusion and continuous high-shear wet-granulation capabilities.

The 18mm extruder will blend into Bend Research’s science and engineering-based workflows for amorphous dispersions. It also enhances the company’s core offerings in oral solubilization, including spray-dried dispersions (SDDs) and crystal size reduction.
 
“As a leader in solubility enhancement and an expert in hot-melt extrusion, we work hard to continually improve and expand in ways that minimize the time, money, and active pharmaceutical ingredient required to advance these projects,” said Rod Ray, chairman and chief executive officer at Bend Research. “The addition of this equipment enables us to use less API during formulation and process development, as well as allows for more facile transfer and scale-up from development through clinical trial manufacturing in our cGMP manufacturing facility.”

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